In particular, tomato sauce consumption may play a role in reducing TMPRSS2:ERG-positive disease. Inverse probability weighting did not materially change the results.Ĭonclusions: Our results lend some support to the hypothesis that prostate cancers that harbor TMPRSS2:ERG may be etiologically distinct from fusion-negative cancers. Increasing quintiles of lycopene intake were associated with a decreased risk of both subtypes ( P-heterogeneity = 0.79). With respect to molecular subtypes, cumulative average tomato sauce intake was associated with a decreased risk of ERG-positive disease (HR: 0.54 95% CI: 0.37, 0.81 P-trend = 0.004) but not with ERG-negative disease (HR: 0.96 95% CI: 0.62, 1.50 P-trend = 0.10) ( P-heterogeneity = 0.04). With inclusion of only the latter cases, increasing cumulative average tomato sauce intake was associated with a decreased risk of prostate cancer overall (≥2 servings/wk compared with <1 serving/mo multivariable HR: 0.70 95% CI: 0.52, 0.95 P-trend = 0.002). Results: During 23 y of follow-up, 5543 men were diagnosed with prostate cancer, among whom 884 were assayed for ERG (426 ERG-positive).
We implemented inverse probability weighting to account for evaluating ERG status only in surgically treated cases. We used multivariable competing risk models to calculate HRs and 95% CIs for the risk of ERG-positive and, separately, ERG-negative disease. TMPRSS2:ERG was assessed by ERG immunohistochemistry on tumor tissue microarrays constructed from radical prostatectomy specimens. Objective: We aimed to examine associations between estimated lycopene and tomato sauce intake and the risk of prostate cancer defined by ERG protein expression subtype.ĭesign: Our study population consisted of a prospective cohort of 46,719 men from the Health Professionals Follow-Up Study. Given their antioxidant properties, we hypothesized that lycopene and tomato sauce may be especially protective against diseases harboring the common gene fusion transmembrane protease, serine 2 ( TMPRSS2):v-ets avian erythroblastosis virus E26 oncogene homolog ( ERG). Background: There is limited evidence that supports etiologically distinct molecular subtypes of prostate cancer, the identification of which may improve prevention.
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